Now pains and numbness can be controlled by Chilli peppers
May 20, 2008
Washington - Scientists have been able to block the pain and numb feeling that lingers long in the gums after a visit to the dentist - thanks to chilli peppers. Harvard scholars shared an in-active plagiaristic of a local anesthetic called QX314 with capsaicin, the ache building agent in chilli peppers to produce the blocking effect. Capsaicin works by notching channels there only in ache fibers to allow QX314 only into these cells where it blocks their purpose, said Clifford Woolf, who led the study.
“This is the first example of using the body’s own cellular channels as a drug delivery system, targeting treatment only at pain fibers,” he said. “These common analgesics, including QX314, however, affect all neurons in the treated area,” Woolf said.
Since local anesthetics only operate within neurons, an injection of QX314 alone is unproductive. As QX314 only enters pain neurons and, thus, acts totally as a pain-killer, the researchers combined it with capsaicin. Capsaicin helps in binding a membrane receptor only there in the membrane of neurons accountable for pain perception. Thus, the chilli pepper opens channels, allowing QX314 to get into the cell and then block the pain receptors. Using rats, the scientists could show that when applied to the animals’ hind paws, the combination of QX314 and capsaicin solely blocks pain receptors.
IANS
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