Washington – Recent researches shows that older people with higher activity of the hormone IGF-1, or insulin growth factor (IGF), emerge to have greater life hope and less cardiovascular danger.IGF-1, a hormone comparable in molecular structure to insulin, is free from the liver and plays an important role in childhood growth and continues to have anabolic effects in adults.
For the research, researchers evaluated 376 healthy old men lying between the age groups of 73 and 94 years.
A serum taster was taken from each member at the beginning of the study and researchers were getting in touch with about the status of the subjects over a period of eight years.
The research displayed that subjects with the lowly IGF-1 function had a considerably higher death rate than subjects with the highest IGF-1 bioactivity.
These new findings come as a result of a new form of testing for IGF-bioactivity. In this study, investigators used a new method, a bioassay, to gauge the function of IGF-1 in the blood.
Opposing to normally used methods to measure IGF-1, the IGF-1 bioassay gives more information about the actual function (bioactivity) of circulating IGF-1 in the body.
“The bioassay allowed us to more clearly see the association between high circulating IGF-1 bioactivity and extended survival,” said Michael Brugts, MD, of the Erasmus Medical Center in Rotterdam, The Netherlands and lead author of the study.
“Interestingly, we could not find such a relationship when IGF-1 in blood was measured with the more commonly used methods,” he added.
The research is available in the Journal of Clinical Endocrinology and Metabolism (JCEM).