Drug for HIV may decrease vision loss
May 26, 2008
Washington – In a recent research done at Harvard Medical School, Boston, and Inserm U848, France has exposed that anti HIV drugs may establish efficient in reducing vision loss.
The study demeanor using a mouse model has shown that anti HIV drugs known as protease inhibitors may reduce the cause of some forms of vision loss.
Vision loss often takes place due to the death (by a process known as apoptosis) of nerve cells in the eye (known as photoreceptors) after retinal detachment.
During the study, mouse with retinal detachment were given HIV protease inhibitors by mouth.
The Scientists established that the drugs lowered photoreceptor apoptosis or nerve cell demise in the eye.
The analysis of mouse retinal cell cultures and those stating reduced amounts of specific proteins showed that the HIV protease inhibitors disturb 2 molecular pathways that caused cell death, both of which influence the cell compartments known as mitochondria.
As the same apoptotic cell death-inducing pathways were shown to be making active in human retinas after retinal aloofness, the authors suggest that although the HIV protease inhibitors can’t reattach the retina, they might be of clinical benefit through their aptitude to stop the photoreceptor apoptosis that has a central role in vision loss after retinal detachment.
(ANI)
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