Huntington’s Disease
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Huntington’s disease is a genetic ailment, which affects the central nervous system. This neurological disorder attacks brain cells and as a result it can incapacitate a person from performing some indispensable works like thinking, talking, reasoning, walking etc.

It has been observed that Western Europeans are more susceptible to this rare disease rather than Africans and Asians. This exceptional genetic disorder is named after renowned physician George Huntington who first discovered this disease in the year 1872. Huntington’s disease generally affects Three to seven persons out of 100,000 Western Europeansand this number can vary with the change of geographical location.

What Causes Huntington’s Disease

Chromosomal deformity is the major cause, which results in Huntington’s disease. The presence of a defective gene in chromosome 4 can cause this disease. This disease damages cerebral cortex and basal ganglia of brain and this leads to emotional, physical and mental complications in future.

The excessive presence of Huntingtin protein, which is known as “Htt” in Huntingtin gene is often due to the trinucleotide expansion and this is another major cause for Huntington’s disease. This rapid expansion of “Htt” protein ultimately damages a person’s brain cells and at times destroys them; this finally leads to the disease.

This disease is essentially inherited. An affected chromosome can be transmitted from parents to an infant.

Symptoms of Huntington’s Disease

The symptoms of Huntington’s disease generally appear when the person is middle aged. However, in some cases the symptoms can appear earlier in a patient’s life. The first and the foremost symptom is the loss of memory and this will certainly bring some inevitable changes in a person’s personality as well as demeanor.

Sometimes a patient may become violent and unfit for social inhabitation. An unnatural movement in muscles is another major symptom associated with this disease. As time passes, the signs of dementedness are noticed.

Lack of concentration and illogical thoughts are also some of the prominent systems of this disease. Nervousness, depression, loss of weight and difficulty in speaking are some of the important signs of this disease. Symptoms of this disease begin to unfold themselves with the passing of time. Unusual facial expression, difficulty in swallowing and lack of proper co-ordination in different parts of a person’s body are some of the pertinent physical symptoms of Huntington’s disease.

Huntington’s Disease Treatment

There are diverse types of supportive cares, which have been developed for people suffering from this disease, and these can help a patient to lead normal life as much as possible. Intrabody Therapy is developed to reduce the severeness of the symptoms of this disease.

Engineered intracellular antibody fragments are used in this therapy efficiently to treat a person who is suffering from this disease. This can efficaciously reduce the formation of mHtt. This therapy can reduce the aggressiveness of this disease in two different types of models: Fly model and drosophila HD model. By delaying the degeneration of nervous system, this therapy can increase the life span of a patient significantly.

Stem Cell implantation is another treatment method that can help a patient to fight against this lethal disease. This treatment is executed by replacing damaged neuron cells by new stem cells and this will certainly reduce the symptoms of this disease. Gene silencing is another important treatment method and it can effectively reduce the expansion of mHtt. This treatment can be used to fix this disease to a certain point.

There are some other treatment methods are available. Creatine, dopamine receptor blockers, tetrabenazine, CoQ10 are medicines which are used for treating a patient. Some medications are also used to treat a patient. For reducing the symptoms of psychological disorder, sedatives and antidepressants are applied. A low dose of antipsychotic drug is also used for treating a patient.


Though Huntington’s disease is not absolutely curable, medications and care can reduce the severity of the symptoms of this disease. As body weight usually reduces in this disease, proper nutritious foods have to be supplied to a patient. One can consult with a nutritionist for preparing a perfect chart of nutrition.

If a patient is facing problem in swallowing solid food, needs to be provided with liquid food. A stomach PEG can be used in this particular situation if a patient is facing too much problem.

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