Hughes Syndrome
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Hughes syndrome is responsible for unnatural coagulation of blood in a person’s veins and arteries. This syndrome is also responsible for some pregnancy related complications. Antibodies’ reaction against a cell membrane is the cause behind the occurrence of this syndrome. This syndrome is often termed as Antiphospholipid syndrome. Actually the term “Hughes syndrome” originated from the name of renowned rheumatologist Dr. Graham R.V. Hughes who first worked extensively on this syndrome.

Hughes syndrome is responsible for lethal heart attack and strokes. It has been observed that 1 out of 5 people, who have experienced heart attack, have been suffering from Hughes syndromes.

Symptoms of Hughes Syndrome

The symptoms of Hughes syndrome are severe and if they are not heeded with caution they can bring catastrophic consequences in near future. Coagulation of blood i.e. a process in which blood loses its liquidity and converts itself into a semisolid mass is one of the conspicuous symptoms of this syndrome. This is also known as thrombosis and this can occur in arms, legs and even in some internal organs like liver, brain, eye, kidney, lungs etc.

Neurological disorder and frequent headache are some important signs that show the presence of the syndrome. Skin rash which is known as livedo reticularis in medical terminology and loss of memory are also some of the important signs which indicate the presence of Hughes syndrome. Spasmodic movement in some parts of the body due to damage in nervous system is another symptom of this disease.

Apart from that, unusual complications in pregnancy and mild thrombocytopenia are two pertinent findings which are associated with this syndrome. This syndrome generally increases the risk of miscarriage. As it coagulates blood in the blood vessels, sticky blood can’t pass thought the blood vessel of a baby who is growing in the womb of a pregnant woman. This often leads to miscarriage.

Causes of Hughes Syndrome

Abnormal reactions of some antibodies against a fat molecule that surrounds each and every cell, is the reason behind this complication. The presence of Hughes syndrome incites antibodies of a person to produce antigen against the presence of phospholipids which are present in cell membranes.

Usually, antibody produces antigen to fight against some noxious elements like bacteria, virus etc. But Hughes syndrome changes their targets and these antibodies then begin to destroy the immunity system of the body. This leads to autoimmune disease.

Hughes syndrome can emerge in a person’s body independently or it can appear associated with another lethal autoimmune disease.

Treatment for Hughes Syndrome

Heparin or Aspirin is generally used in treating the complexities due to the presence of the Hughes syndrome in a person’s body. Thrombosis and the coagulation of blood can be treated successfully by applying these drugs. A low dose of medication can decrease the severity of the symptoms that is associated with the presence of the Hughes syndromes.

The treatment of a pregnant woman is different because the health of fetus is associated with it. It has been noticed that the risk of miscarriage can be reduced remarkably if heparin injection is given and small aspirin can be taken regularly for women suffering from this ailment.

If the problem of blood coagulation is becoming very problematic, Warfarin can be given to tackle this problem. Warfarin acts as an anticoagulant but pregnant women should not take this medication because of the teratogenicity of Warfarin.

The presence of Hughes syndrome in ones body can be determined by testing in the laboratory by using solid phrase ELISA assays and by using liquid phase coagulation assays. This will help to assess the presence of anticardiolipin antibodies in a patient body.


Any person from any age group can be affected by the presence of Hughes syndrome which will in turn ultimately bring some inevitable catastrophic consequences in near future like triggering a heart attack.

However, it has been observed that women are generally susceptible to this disease. If it is a case of pregnant woman, she needs to undergo some clinical tests for determining her present health condition. “Anticardiolipin antibodies” is one of the most important tests that have to be executed to assess health condition.

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i have an appt the 13th w/ a hematologist to get tested for APS. Ive had 1 miscarriage, and 2 stillborns which is what prompted my OB/GYN to say i should get tested. the problem however, is it has taken 13+ yrs to get too this appt, and since i have noticed other 'signs' than just the pregnancy losses which were more than bad enough. so im hopin & prayin this appt will give me some answers i have long been waiting for.
#1 - Dawn Smith Lee - 03/11/2013 - 14:52
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